There was a significant decline in the incidence of invasive prenatal testing over the 12 years of the study. Advanced maternal age as the sole indication for invasive procedures decreased significantly over time, while the indication of abnormal serum screening and abnormal ultrasound findings increased (p < 0.01). In addition, in 765 (2.5%) cases, chorionic villus sampling (CVS) was performed in period 1, compared to 1,174 (3.0%) cases in period 2 and 251 (1.3%) cases in period 3 (p < 0.01). The first part of the SS is generally performed in the first trimester and consists of a blood draw from mom and an ultrasound. If your risk for abnormality is high during Part 1, you’ll have the option to explore more detailed or invasive testing for diagnoses, which is completely optional. Sequential Screen 2018 GSF Patient Library 1 Sequential screening (SS) is a test that can tell the chance that a pregnancy has Down syndrome (trisomy 21), trisomy 18, and open neural tube defects (ONTDs).
In period 1, there were 1,990 (6.3%) cases of amniocentesis, 1,646 (4.3%) in period 2, and 254 (1.2%) in period 3 (p < 0.01). As can be deduced from its name, the Sequential Screen is the product of potentially two, sequential screening procedures. There were 88,135 deliveries and 6,080 invasive procedures during the study period. The main outcome measures were trends in the incidence and method of each procedure. This is a retrospective review of all pregnancies that have undergone invasive prenatal diagnostic testing between June 2002 and June 2014, divided in 3 periods: period 1 from June 2002 to October 2006, period 2 from November 2006 to December 2011, and period 3 from January 2012 to June 2014. To examine trends in the incidence and method of invasive prenatal diagnosis due to the impact of sequential screening and noninvasive prenatal testing.
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